Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells
Identifieur interne : 004098 ( Main/Exploration ); précédent : 004097; suivant : 004099Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells
Auteurs : Fabrizio Poccia [Italie] ; Chiara Agrati ; Concetta Castilletti ; Licia Bordi ; Cristiana Gioia ; Douglas Horejsh ; Giuseppe Ippolito [Italie] ; Paul K. S. Chan [République populaire de Chine] ; David S. C. Hui [République populaire de Chine] ; Joseph J. Y. Sung [République populaire de Chine] ; Maria Rosaria Capobianchi ; Miroslav MalkovskySource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Récepteur lymphocytaire T antigène, gamma-delta.
- immunologie : Sous-populations de lymphocytes T, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G.
- Adulte, Femelle, Humains, Mâle, Mémoire immunologique.
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Coronavirus, Female, Humans, Immune response, Immunoglobulin G (blood), Immunologic Memory, Infection, Male, Microbiology, Receptors, Antigen, T-Cell, gamma-delta (analysis), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe acute respiratory syndrome, T-Lymphocyte, T-Lymphocyte Subsets (immunology).
- MESH :
- chemical , analysis : Receptors, Antigen, T-Cell, gamma-delta.
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocyte Subsets.
- Adult, Female, Humans, Immunologic Memory, Male.
Abstract
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti–SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ–dependent anti–SARS-CoV activity and are able to directly kill SARS-CoV–infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS
Url:
- https://api.istex.fr/ark:/67375/HXZ-220KSMNH-B/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110256
DOI: 10.1086/502975
Affiliations:
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Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti–SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ–dependent anti–SARS-CoV activity and are able to directly kill SARS-CoV–infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS</div></front></TEI><affiliations><list><country><li>Italie</li><li>République populaire de Chine</li></country><region><li>Latium</li></region><settlement><li>Rome</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name></noCountry><country name="Italie"><noRegion><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name></noRegion><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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